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Dosie™ modeling software predicts better PDT outcomes.

January 31, 2019

SPIE BiOS, 2019 (Optical Methods for Tumor Treatment and Detection) – We introduce our Dosie modeling software that helps in predicting outcomes of Photodynamic therapy (PDT) against cancer. It can be used as a dosimetry and treatment planning software for intracavitary and surface PDT. Three types of doses can be monitored: (conventional) light dose, PDT-dose, and the reacted singlet oxygen dose.

 

Our presentation at Photonics West 2019, BiOS:

Meeting: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII

Session 7: Photodynamic therapy VII

Location: Room 307 (South Level Three) 

When: Sunday 3 February 2019, 2:40 PM - 3:00 PM

 

Abstract:

We compare previously reported 2-(1-hexyloxyethyl)-2-divinyl pyropheophorbide (HPPH) mediated photodynamic therapy (PDT) results for singlet oxygen dose on mice with simulations using DosieSOFT, a new simulation software that accurately calculates light transport and photokinetics for PDT. The computational results validate the predictive quality of the simulations for HPPH (Photoclor) mediated PDT in mice studies.

 

 

Figure 2. Dosie™ GUI screenshot: MC fluence rate results using 0.50-mm voxels for an incident fluence rate of 150 mW/cm2. Volume rendering (tilted) to visualize 3D fluence rate map is shown in the upper left view. The other views show 2D cross-sections (slices) of the 3D map – sagittal, coronal and transverse views.

 

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