Clinical trial publications
Penn
Ivanick, N. M, and Shafirstein, G. et. al. (2022)
First-In-Human Computer-Optimized Endobronchial Ultrasound-Guided Interstitial Photodynamic Therapy for Patients With Extrabronchial or Endobronchial Obstructing Malignancies, JTO Clin Res Rep, v.3(10), 2022 Oct ; 10.1016/j.jtocrr.2022.100372
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Phase I
-
8 patients
Penn
Friedberg, J.S. et. al. (2017)
Extended Pleurectomy-Decortication–Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years, Ann Thorac Surg, 103:912–9; doi:10.1016/j.athoracsur.2012.02.009
Phase II clinical trial-breatkthrough
73 patients
Median overall survival was 3 years compared to about 1 year for SoC
Penn
Friedberg, J.S. et. al. (2012)
Radical Pleurectomy and Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma, Ann Thorac Surg, 93:1658–67 doi:10.1016/j.athoracsur.2012.02.009
Phase I clinical
Roswell
Rohrbach, D. J. et. al.( 2016)
Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma J.Biomed. Opt. 21, 018002; DOI: 10.1117/1.JBO.21.1.018002
Phase I
Roswell
Shafirstein, G, et. al.( 2016)
Photodynamic therapy with 3-(10 -hexyloxyethyl) pyropheophorbide-a for early-stage cancer of the larynx: Phase Ib study, Head and Neck , E377-E383 (2016) DOI10.1002/hed.24003
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Phase Ib
Roswell
Rigual, N. et.al. (2013)
Photodynamic Therapy with 3-(1’-hexyloxyethyl) pyropheophorbide a (HPPH) for Cancer of the Oral Cavity, Clin Cancer Res. 19: 6605–6613. doi:10.1158/1078-0432.CCR-13-1735
Phase I
Roswell
Rigual, N. et.al. (2013)
Adjuvant Intraoperative Photodynamic Therapy in Head and Neck Cancer
JAMA Otolaryngol Head Neck Surg,139:706-711. doi:10.1001/jamaoto.2013.3387
Phase I
Technical Publications
Simphotek
Beeson, K.W. et. al. (2019)
Validation of combined Monte Carlo and photokinetic Simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice,
J. Biomed. Opt. 24, 035006, doi: 10.1117/1.JBO.24.3.035006.
with Penn
Zhu,T.C. et. al. (2018)
Light fluence dosimetry in lung simulating cavities” Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII,
Proc. of SPIE 104760F doi:10.1117/12.2291355
with Roswell
Sharfirstein,G. et. al. (2017)
Interstitial Photodynamic Therapy—Focused Review,
Cancers, 9,12; doi:10.3390/cancers9020012
Simphotek
Beeson, K.W. et. al. (2017)
Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen,
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, Proc. of SPIE, 100470R, doi: 10.1117/12.2252552
Presentations | Conferences
Simphotek
Parilov, E, and Beeson, K.W. et. al. (2023)
A Monte Carlo simulation for moving light source in intracavity PDT,
Photonics West, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, San Francisco, CA Jan 28
with Penn
Sun, Hongjing et. al. (2023)
A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system,
Photonics West, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, San Francisco, CA Jan 28
Simphotek
Beeson, K.W. et. al. (2019)
Validation of DosieTM combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated PDT on mice,
Photonics West, San Francisco, CA Feb 3
with Penn
Zhu,T.C. et. al. (2018)
Light fluence dosimetry in lung simulating cavities,
Photonics West, San Francisco, CA, Jan 28
Simphotek
Beeson, K.W. et. al. (2017)
Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen,
Photonics West San Francisco, CA
Related publications
Penn
Zhu,T.C. et. al. (2020)
Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT)
Photochem Photobiol. 2020 Mar;96(2):310-319.
doi: 10.1111/php.13166
Penn
Zhu,T.C. et. al. (2020)
Infrared navigation system for light dosimetry during pleural photodynamic therapy,
Phys Med Biol. 2020 Apr 14; 65(7): 075006.
doi: 10.1088/1361-6560/ab7632
Roswell
Schafirstein, G. et.al. (2020)
Irradiance, Photofrin® Dose and Initial Tumor Volume are Key Predictors of Response to Interstitial Photodynamic Therapy of Locally Advanced Cancers in Translational Models,
Photochem Photobiol. 2020 Mar-Apr; 96(2): 397–404
doi: 10.1111/php.13207
Penn
Ong, Y.H.et.al. (2018)
PDT dose dosimetry for Photofrin-mediated pleural photodynamic therapy (pPDT),
Phys. Med. Biol. 63 015031
Penn
Kim, M.M. et.al. (2017)
Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy,
J. Biomed. Opt. 22(2), 028002 (2017), doi: 10.1117/1.JBO.22.2.028002
Penn
Penjweini, R. et. al. (2016)
Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling,
J. Biophotonics 1–11 (2016) : DOI 10.1002/jbio.201600121
Catholic University of Leuven
Adostinis, P. et. al. (2011)
Photodynamic Therapy of Cancer: An Update,
CA Cancer J Clin 2011;61:250-281; doi:10.3322/caac.20114
Roswell
Schafirstein, G. et.al. (2019)
Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer,
British Journal of Cancer , doi.org/10.1038/s41416-018-0210-y
Roswell
Mimikos, C. et. al. (2016)
Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma,
World Journal of Otorhinolargology: Head and Neck Surgery 2, 126, doi.org/10.1016/j.wjorl.2016.05.011
Roswell
Oakley, E, et.al. (2015)
A New Finite Element Approach for Near Real-Time Simulation of Light Propagation in Locally Advanced Head and Neck Tumors,
Lasers in Surgery and Medicine 47:60–67; DOI 10.1002/lsm.22313