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Clinical trial publications of our academic partners

Roswell

Ivanick, N. M, and Shafirstein, G. et. al. (2022)

First-In-Human Computer-Optimized Endobronchial Ultrasound-Guided Interstitial Photodynamic Therapy for Patients With Extrabronchial or Endobronchial Obstructing Malignancies,  JTO Clin Res Rep, v.3(10), 2022 Oct ;    10.1016/j.jtocrr.2022.100372  

  • Phase I

  • 8 patients

Penn

Friedberg, J.S. et. al. (2017)

Extended Pleurectomy-Decortication–Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years,  Ann Thorac Surg, 103:912–9;    doi:10.1016/j.athoracsur.2012.02.009  

  • Phase II clinical trial-breatkthrough

  • 73 patients

  • Median overall survival was 3 years compared to about 1 year for SoC

Penn

Friedberg, J.S. et. al. (2012)

Radical Pleurectomy and Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma,  Ann Thorac Surg, 93:1658–67  doi:10.1016/j.athoracsur.2012.02.009

  • Phase I clinical   

Roswell

Rohrbach, D. J. et. al.( 2016)

Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma   J.Biomed. Opt.   21, 018002; DOI: 10.1117/1.JBO.21.1.018002

  • Phase I

Roswell

Shafirstein, G, et. al.( 2016)

Photodynamic therapy with 3-(10 -hexyloxyethyl) pyropheophorbide-a for early-stage cancer of the larynx: Phase Ib study,  Head and Neck , E377-E383 (2016) DOI10.1002/hed.24003

  • Phase Ib

Roswell

Rigual, N. et.al. (2013)

Photodynamic Therapy with 3-(1’-hexyloxyethyl) pyropheophorbide a (HPPH) for Cancer of the Oral Cavity,    Clin Cancer Res. 19: 6605–6613. doi:10.1158/1078-0432.CCR-13-1735

  • Phase I

Roswell

Rigual, N. et.al. (2013)

Adjuvant Intraoperative Photodynamic Therapy in Head and Neck Cancer

JAMA Otolaryngol Head Neck Surg,139:706-711. doi:10.1001/jamaoto.2013.3387

  • Phase I

Technical Publications

with Roswell

Oakley, E., and Parilov, E.  et. al. (2023)  

Computational Optimization of Irradiance and Fluence for Interstitial Photodynamic Therapy Treatment of Patients with Malignant Central Airway Obstruction,

Cancers. 15(9) : 2636, doi:10.3390/cancers15092636.

Simphotek

Beeson, K.W.  et. al. (2019)  

Validation of combined Monte Carlo and photokinetic Simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice,

J. Biomed. Opt. 24, 035006, doi: 10.1117/1.JBO.24.3.035006.

with Penn

Zhu, T.C. et. al. (2018)

Light fluence dosimetry in lung simulating  cavities”  Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII,

Proc. of SPIE 104760F  doi:10.1117/12.2291355 

with Roswell

Sharfirstein, G. et. al. (2017)

Interstitial Photodynamic Therapy—Focused Review,

Cancers, 9(2) :12; doi:10.3390/cancers9020012

Simphotek

Beeson, K.W.  et. al. (2017)

Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen,

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, Proc. of SPIE, 100470R,  doi: 10.1117/12.2252552

Presentations | Conferences

Simphotek

Parilov, E, and Beeson, K.W.  et. al. (2023)  

A Monte Carlo simulation for moving light source in intracavity PDT,

Photonics West, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, San Francisco, CA Jan 28

with Penn

Sun, Hongjing  et. al. (2023)  

A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system,

Photonics West, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, San Francisco, CA Jan 28

Simphotek

Beeson, K.W.  et. al. (2019)  

Validation of DosieTM combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated PDT on mice,

Photonics West, San Francisco, CA Feb 3

with Penn

Zhu, T.C. et. al. (2018)

Light fluence dosimetry in lung simulating  cavities,

Photonics West, San Francisco, CA, Jan 28

Simphotek

Beeson, K.W.  et. al. (2017)

Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen,

Photonics West  San Francisco, CA

Related publications

Penn

Zhu, T.C. et. al. (2020)

Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT)

Photochem Photobiol. 2020 Mar;96(2):310-319.

doi: 10.1111/php.13166

Penn

Zhu, T.C. et. al. (2020)

Infrared navigation system for light dosimetry during pleural photodynamic therapy,

Phys Med Biol. 2020 Apr 14; 65(7): 075006.

doi: 10.1088/1361-6560/ab7632

Roswell

Schafirstein, G. et.al. (2020)

Irradiance, Photofrin® Dose and Initial Tumor Volume are Key Predictors of Response to Interstitial Photodynamic Therapy of Locally Advanced Cancers in Translational Models,

Photochem Photobiol. 2020 Mar-Apr; 96(2): 397–404

doi: 10.1111/php.13207

Penn

Ong, Y.H.et.al.  (2018)

PDT dose dosimetry for Photofrin-mediated pleural photodynamic therapy (pPDT),

Phys. Med. Biol. 63 015031

Penn

Kim, M.M. et.al. (2017)

Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy,

J. Biomed. Opt. 22(2), 028002 (2017), doi: 10.1117/1.JBO.22.2.028002

Penn

Penjweini, R. et. al. (2016)

Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling,

J. Biophotonics 1–11 (2016) : DOI 10.1002/jbio.201600121

Catholic University of Leuven

Adostinis, P. et. al. (2011)

Photodynamic Therapy of Cancer: An Update,

CA Cancer J Clin 2011;61:250-281; doi:10.3322/caac.20114

Roswell

Schafirstein, G. et.al. (2019)

Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer,

British Journal of Cancer , doi.org/10.1038/s41416-018-0210-y

Roswell

Mimikos, C. et. al. (2016)

Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma,

World Journal of Otorhinolargology: Head and Neck Surgery 2, 126,   doi.org/10.1016/j.wjorl.2016.05.011

Roswell

Oakley, E, et.al. (2015)

A New Finite Element Approach for Near Real-Time Simulation of Light Propagation in Locally Advanced Head and Neck Tumors,

Lasers in Surgery and Medicine 47:60–67;   DOI 10.1002/lsm.22313

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