Clinical trial publications

Penn

Friedberg, J.S. et. al. (2017)

Extended Pleurectomy-Decortication–Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years, Ann Thorac Surg, 103:912–9; doi:10.1016/j.athoracsur.2012.02.009

Phase II clinical trial-breatkthrough
73 patients
Median overall survival was 3 years compared to about 1 year for SoC

Penn

Friedberg, J.S. et. al. (2012)

Radical Pleurectomy and Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma, Ann Thorac Surg, 93:1658–67 doi:10.1016/j.athoracsur.2012.02.009

Phase I clinical

Roswell

Rohrbach, D. J. et. al.( 2016)

Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma J.Biomed. Opt. 21, 018002; DOI: 10.1117/1.JBO.21.1.018002

Phase I

Roswell

Shafirstein, G, et. al.( 2016)

Photodynamic therapy with 3-(10 -hexyloxyethyl) pyropheophorbide-a for early-stage cancer of the larynx: Phase Ib study, Head and Neck , E377-E383 (2016) DOI10.1002/hed.24003

Phase Ib

Roswell

Rigual, N. et.al. (2013)

Photodynamic Therapy with 3-(1’-hexyloxyethyl) pyropheophorbide a (HPPH) for Cancer of the Oral Cavity, Clin Cancer Res. 19: 6605–6613. doi:10.1158/1078-0432.CCR-13-1735

Phase I

Roswell

Rigual, N. et.al. (2013)

Adjuvant Intraoperative Photodynamic Therapy in Head and Neck Cancer

JAMA Otolaryngol Head Neck Surg,139:706-711. doi:10.1001/jamaoto.2013.3387

Phase I

Technical Publications

Simphotek

Beeson, K.W. et. al. (2019)

Validation of combined Monte Carlo and photokinetic Simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice,

J. Biomed. Opt. 24, 035006, doi: 10.1117/1.JBO.24.3.035006.

with Penn

Zhu,T.C. et. al. (2018)

Light fluence dosimetry in lung simulating cavities” Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII,

Proc. of SPIE 104760F doi:10.1117/12.2291355

with Roswell

Sharfirstein,G. et. al. (2017)

Interstitial Photodynamic Therapy—Focused Review,

Cancers, 9,12;doi:10.3390/cancers9020012

Simphotek

Beeson, K.W. et. al. (2017)

Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen,

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, Proc. of SPIE, 100470R, doi: 10.1117/12.2252552

Presentations | Conferences

Simphotek

Beeson, K.W. et. al. (2019)

Validation of DosieTM combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated PDT on mice,

Photonics West, San Francisco, CA Feb 3

with Penn

Zhu,T.C. et. al. (2018)

Light fluence dosimetry in lung simulating cavities,

Photonics West, San Francisco, CA, Jan 28

Simphotek

Beeson, K.W. et. al. (2017)

Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen,

Photonics West San Francisco, CA

Related collaborator publications

Penn

Ong, Y.H.et.al. (2018)

PDT dose dosimetry for Photofrin-mediated pleural photodynamic therapy (pPDT),

Phys. Med. Biol. 63 015031

Penn

Kim, M.M. et.al. (2017)

Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy,

J. Biomed. Opt. 22(2), 028002 (2017), doi: 10.1117/1.JBO.22.2.028002

Penn

Penjweini, R. et. al. (2016)

Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling,

J. Biophotonics 1–11 (2016) : DOI 10.1002/jbio.201600121

Catholic University of Leuven

Adostinis, P. et. al. (2011)

Photodynamic Therapy of Cancer: An Update,

CA Cancer J Clin 2011;61:250-281; doi:10.3322/caac.20114

Roswell

Schafirstein, G. et.al. (2019)

Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer,

British Journal of Cancer , doi.org/10.1038/s41416-018-0210-y

Roswell

Mimikos, C. et. al. (2016)

Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma,

World Journal of Otorhinolargology: Head and Neck Surgery 2, 126, doi.org/10.1016/j.wjorl.2016.05.011

Roswell

Oakley, E, et.al. (2015)

A New Finite Element Approach for Near Real-Time Simulation of Light Propagation in Locally Advanced Head and Neck Tumors,

Lasers in Surgery and Medicine 47:60–67; DOI 10.1002/lsm.22313