Dosie™ adds modeling Interstitial Photodynamic Therapy (I-PDT)

International Photodynamic Association World Congress, 2019 (Boston, USA) – Simphotek announces a new addition to its simulation software Dosie™ - near real-time finite element (FE) solver that accurately simulates light intensity distribution for interstitial type PDT. The new module is integrated with Dosie photokinetics that allows to estimate delivered PDT dose and (reacted) singlet oxygen dose in minutes.

Our poster at IPA 2019: Fast and Accurate Simulation for PDT dosimetry

Authors: Mary J. Potasek,Karl Beeson, Evgueni Parilov, Simphotek Inc. (USA); Gal Shafirstein,Emily Oakley, David Bellnier, Roswell Park Comprehensive CancerCtr. (USA)

Location: Salons 1-3

When: Sunday 30 June 2019, 4:30 PM - 6:30 PM

Abstract:

We report incorporating finite-element-based light propagation simulations with photokinetics of the light-activated drug (PS) to create a dosimetry system for light fluence rate, fluence, and induced fluorescence, in near real-time and in 3D, for PDT treatment in the clinic. Recent experiments in phantoms at Roswell Park Cancer Institute show excellent agreement with calculations. Future efforts will develop a novel hardware and software prototype platform with feedback and monitoring that integrates real-time light and PS dosimetry.

Dosie™ GUI screenshot: FE fluence rate map of I-PDT light; 3 holes correspond to 3 fibers inserted into the tumor; 2 fibers emits light, while one fiber was turned off.